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Updated: May 8, 2026

A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform
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Osteocalcin promotes β-cell proliferation during development and adulthood through Gprc6a

Jianwen Wei1, Timothy Hanna, Nina Suda

  • 1Department of Genetics & Development, College of Physicians and Surgeons, Columbia University, New York, NY.

Diabetes
|September 7, 2013
PubMed
Summary

Osteocalcin, a bone hormone, promotes beta-cell replication via Gprc6a signaling, crucial for insulin production and managing diabetes. This pathway regulates beta-cell mass during development and adulthood.

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