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Published on: July 17, 2018
Adiponectin concentration in the orbital fat of patients with Graves' ophthalmopathy
Uri Soiberman1, Ran Levy, Igal Leibovitch
1Department of Ophthalmology, Tel Aviv Medical Center, Israel ; sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Background:
"Graves' ophthalmopathy" (GO), is an inflammatory disease of the orbit, with extensive adipose tissue involvement. Previous studies of orbital fat derived from such patients have demonstrated overexpression of the adiponectin gene and messenger RNA.
Aim:
The study reported here aimed to measure the protein concentration of orbital adipose tissue adiponectin in GO patients, in comparison to healthy controls.
Methods:
This was a prospective study. Orbital samples from ten healthy controls undergoing blepharoplasty and five patients with GO undergoing orbital fat decompression for proptosis were analyzed by enzyme-linked immunosorbent assay.
Results:
The mean adiponectin concentration in samples from GO patients was 121.9 ± 29.5 ng/mL (mean ± standard deviation), versus 107.9 ± 26.6 ng/mL in the control group (P=0.20).
Conclusion:
This study was unable to demonstrate a statistically significant difference in adiponectin protein concentrations between the two studied groups.
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