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AKT-independent PI3-K signaling in cancer - emerging role for SGK3

Maressa A Bruhn1, Richard B Pearson, Ross D Hannan

  • 1Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia ; School of Biological Sciences, Flinders University, Bedford Park, South Australia, Australia.

Cancer Management and Research
|September 7, 2013
PubMed

Insights

The serum- and glucocorticoid-inducible protein kinase 3 (SGK3) is crucial for cancer cell growth. This review highlights SGK3

Area of Science:

  • Molecular Biology
  • Oncology
  • Cell Signaling

Background:

  • The phosphoinositide 3-kinase (PI3-K)/protein kinase B (AKT) pathway regulates cell growth, proliferation, and survival.
  • Dysregulation of the PI3-K/AKT pathway is common in cancer, making AKT kinase family members important therapeutic targets.
  • The serum- and glucocorticoid-inducible protein kinase (SGK) family, including SGK3, are PI3-K-dependent kinases with functions similar to AKT.

Purpose of the Study:

  • To review the role of SGK3 in cancer.
  • To focus on SGK3 as a key effector of AKT-independent PI3-K oncogenic signaling.

Main Methods:

  • Literature review of existing research on SGK3 and PI3-K signaling.
  • Analysis of emerging evidence on SGK3's role in oncogenic signaling pathways.

Main Results:

  • SGK3 regulates cellular processes such as proliferation and survival, similar to AKT.
  • Emerging evidence indicates SGK3 plays a critical role in AKT-independent oncogenic signaling.

Conclusions:

  • SGK3 is a significant regulator of cellular processes relevant to cancer.
  • SGK3 represents a key effector in AKT-independent PI3-K oncogenic signaling pathways.
  • Further investigation into SGK3's role may reveal new therapeutic strategies for cancer.
Keywords:
AKTPI3-kinaseSGK3cancermTOR

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