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Related Concept Videos

Glycocalyx and its Functions01:14

Glycocalyx and its Functions

The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.
Components of...
Protein Glycosylation01:25

Protein Glycosylation

Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
Proteoglycans01:05

Proteoglycans

Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
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Microbial Interactions: Parasitism

Parasitism is a form of microbial interaction in which parasitic microbes exploit a host organism for nutrients and shelter, often at the host's expense. Unlike mutualistic relationships, where both organisms benefit, parasitism benefits only the parasite and harms the host.Classification of ParasitesMicrobial parasites are broadly classified based on their location relative to the host.Ectoparasites remain on the host’s surface, such as the skin or outer tissues, drawing nutrients...
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Colonisation of Pathogens

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Conjugated Proteins

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Updated: May 8, 2026

Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes
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Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes

Published on: December 19, 2020

Glycoconjugates in host-helminth interactions.

Nina Salinger Prasanphanich1, Megan L Mickum, Jamie Heimburg-Molinaro

  • 1Department of Biochemistry, Glycomics Center of Emory University, Emory University School of Medicine , Atlanta, GA , USA.

Frontiers in Immunology
|September 7, 2013
PubMed
Summary
This summary is machine-generated.

Helminth worms have unique sugars called glycans that impact host immunity. Understanding these helminth glycans could lead to new treatments for autoimmune diseases and better vaccines.

Keywords:
C-type lectinadaptive immunityanti-glycan antibodiesglycansglycoconjugateshelminthsinnate immunityschistosomiasis

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Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions
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Bioinformatics Resources for the Study of Glycan-Mediated Protein Interactions

Published on: January 20, 2022

Area of Science:

  • Parasitology
  • Immunology
  • Glycobiology

Background:

  • Helminths are parasitic worms causing global health issues.
  • Helminth glycans significantly influence host immune responses.
  • These glycans are a potential source for novel therapeutics and diagnostics.

Purpose of the Study:

  • To review current knowledge on helminth glycan-host immunity interactions.
  • To identify knowledge gaps relevant to therapeutic and diagnostic applications.
  • To highlight the potential of helminth glycans in medicine.

Main Methods:

  • Literature review of studies on helminth glycans and host immunity.
  • Analysis of the immunomodulatory and antigenic properties of helminth glycans.
  • Synthesis of information on therapeutic, vaccine, and diagnostic potential.

Main Results:

  • Helminth glycans modulate both innate and adaptive immunity.
  • Specific helminth glycans show potential as anti-inflammatory agents.
  • Antigenic helminth glycans are promising for vaccine and diagnostic development.

Conclusions:

  • Helminth glycans offer a rich source of immunomodulatory compounds.
  • Further research into helminth glycans can advance treatments for inflammatory disorders.
  • Exploiting helminth glycans is key for developing new vaccines and diagnostics.