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Tramadol induced seizure: A 3-year study.

Reza Boostani¹, Siavash Derakhshan

¹Department of Neurology, Mashhad University of Medical Sciences, Mashhad, Iran.

Caspian Journal of Internal Medicine

|September 7, 2013

Summary

Tramadol, a synthetic analgesic, is linked to seizures, particularly generalized tonic-clonic seizures within 24 hours of use. This risk increases with concurrent use of alcohol, illicit drugs, or certain psychiatric medications.

Keywords:

Electroencephalograms Seizure Tramadol

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Area of Science:

Neuroscience
Pharmacology
Clinical Neurology

Background:

Tramadol is a widely used synthetic analgesic.
Seizures are a reported adverse effect associated with tramadol use.
The correlation between tramadol consumption and seizure occurrence requires further investigation.

Purpose of the Study:

To evaluate the correlation between tramadol consumption and seizure occurrence.
To characterize the clinical presentation and EEG findings in patients experiencing seizures related to tramadol.
To identify risk factors associated with tramadol-induced seizures.

Main Methods:

A cohort of 28 subjects with a history of tramadol consumption and seizures was studied.
Electroencephalograms (EEG) were performed at baseline and one week later.
Subjects were followed for a mean of 18 months post-seizure.

Main Results:

The majority of subjects (92.8%) were male, with a mean age of 28.4 years.
Seizures occurred within 24 hours of tramadol intake in 25 subjects (89.3%).
Abnormal EEG findings were more frequent on initial assessment (12/28) compared to follow-up (1/28).

Conclusions:

Tramadol neurotoxicity commonly presents as generalized tonic-clonic seizures.
Seizures typically occur within 24 hours of tramadol intake.
Concomitant use of alcohol, illicit drugs, antipsychotics, or antidepressants increases seizure risk.