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Updated: May 8, 2026

Synthesis of Immunotargeted Magneto-plasmonic Nanoclusters
Published on: August 22, 2014
A chemical quenching- and physical blocking-based method to minimize process-mediated aggregation of
Chandra K Dixit1, Shibsekhar Roy, Conor Byrne
1School of Biotechnology, Dublin City University, Glasnevin, Dublin 9, Ireland.
Abstract:
Critical limitation of nanoparticles (NP) is their aggregation after functionalisation and antibody cross-linking. We analysed the cause of this aggregation with respect to functionalities (carboxyls and amines) on the NP surface. We have devised a low cost novel method to reduce such aggregations during protein cross-linking and validated it by probing the platelet surface with platelet surface-specific anti-CD41 antibody conjugated NPs.
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