Neurochemical evidence for a nigrotegmental GAbAergic projection
1Department of Pharmacology, Schools of Medicine and Dentistry, Georgetown University, Washington, DC 20007, USA.
Brain Research
|September 10, 2013
Abstract:
Axonal transport of [3H]GABA from substantia nigra to the pontomesencephalic tegmentum was demonstrated in rats pretreated with the GABA-transaminase inhibitor, gamma-vinyl-GABA. In addition, kainic acid lesions of substantia nigra resulted in a significant loss of glutamic acid decarboxylase activity in the vicinity of the ipsilateral pedunculopontine nucleus and in adjacent tissue of the pontomesencephalic tegmentum. These data support the thesis that the nigrotegmental projection is both diffuse and GABAergic.
