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Related Experiment Video

Updated: May 8, 2026

Ultrafast Lignin Extraction from Unusual Mediterranean Lignocellulosic Residues

Ultrafast Lignin Extraction from Unusual Mediterranean Lignocellulosic Residues

Published on: March 9, 2021

[Lignans from Machilus robusta].

Peng-Bin Bu¹, Yan-Ru Li, Ming Jiang

¹State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. lsznn@imm.ac.cn

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica

|September 10, 2013

Summary

This summary is machine-generated.

Eighteen lignans were isolated from Machilus robusta, with (-)-pinoresinol (17) showing significant nitric oxide inhibitory activity in macrophages. This study details novel compounds from this plant source.

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Area of Science:

Phytochemistry
Natural Products Chemistry
Pharmacognosy

Context:

Machilus robusta is a plant species with potential medicinal properties.
Lignans are a class of phenolic compounds found in plants, known for diverse biological activities.
Isolation and characterization of phytochemicals are crucial for drug discovery.

Purpose:

To isolate and identify lignan compounds from the ethanol extract of Machilus robusta.
To characterize the chemical structures of the isolated lignans using spectroscopic methods.
To evaluate the preliminary biological activity of the isolated compounds.

Summary:

Eighteen lignan compounds were successfully isolated from Machilus robusta using advanced chromatographic techniques (silica gel, Sephadex LH-20, reversed-phase HPLC).
Structures were elucidated through comprehensive spectroscopic data analysis, including isolariciresinol-9'-O-beta-D-xylopyranoside (1) and (-)-pinoresinol (17).
All eighteen lignans were reported as new compounds isolated from this plant species for the first time.

Impact:

This research expands the known phytochemical profile of Machilus robusta.
Compound 17, (-)-pinoresinol, demonstrated notable inhibitory activity against nitric oxide (NO) secretion in mouse peritoneal macrophages (72.2% inhibition at 10 µmol/L).
The findings suggest potential therapeutic applications for Machilus robusta-derived lignans, particularly (-)-pinoresinol, in managing inflammatory conditions.