Related Experiment Video
Updated: May 8, 2026
Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice
Published on: August 23, 2024
[Study on effect of psoralidin on anti-experimental postmenopausal osteoporosis and its mechanism]
Jin-Ping Li1, Xiao-Jing Wang, Ying Zeng
1School of Pharmaceutical Sciences, Central South University, Changsha 410013, China. pjingli@163.com
Objective:
To observe the effect of psoralidine in rats with ovariectomy, and preliminarily study its mechanism.
Method:
Sixty female Sprague-Dawley rats were divided into 5 groups: the sham operation group, the model group, the psoralidine low-dose group (4 mg x kg(-1)), the psoralidine high-dose group (16 mg x kg(-1)) and the Zhuangguzhitong capsule group, with 12 rats in each group. Thirteen weeks later, their blood and bone samples were collected to detect bone density, bone biochemistry, pathomorphology, serum E2 and CT.
Result:
Psoralidine could up-regulate the bone density of lumbar vertebra and thighbone of rats with ovariectomy (P < 0.05), the maximum bending strength of thighbone (P < 0.05), and serum E2 and CT (P < 0.05).
Conclusion:
Psoralidine has a good active effect on postmenopausal antiosteoporosis. Its mechanism may be related to such pathways as E2 and CT.
