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[Pharmacokinetics behavior of raltitrexed in rats after single injected with astragali radix]
Rong Xing1, Kai Zhou, Jia-Wei Song
1The First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China. xingrong9796@163.com
Abstract:
To study pharmacokinetics behavior of Raltitrexed (RTX) after single injected with Radix Astragali (RA); twelve rats were divided into two groups: RTX (administrated iv. of raltitrexed); RTX with RA (administrated iv. of raltitrexed after single iv. dose of 3. 15 g x kg(-1)), rat plasma was collected and processed before HPLC assays; The established HPLC method was rapid, specific and precise. Between RTX and RTX with RA groups, half-life (t1/2), AUC(0-t) and CL showed no statistically significant differences; RA co-administration did not affect the pharmacokinetics of raltitrexed.
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