Related Experiment Video
Updated: May 8, 2026
06:53
Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
Published on: November 11, 2016
Chronobiology and obesity
Nutricion Hospitalaria
|September 10, 2013
Summary
Chronobiology reveals that human adipose tissue has internal circadian clocks. Disruptions to these rhythms (chronodisruption) are strongly linked to obesity, offering new insights into the timing of metabolic factors.
Area of Science:
- Chronobiology
- Molecular Biology
- Metabolic Research
Background:
- Circadian molecular clocks regulate 10-30% of the human genome.
- The molecular clock involves transcription factors like CLOCK, BMAL1, PERs, and CRYs.
- Chronodisruption (CD) is a disturbance of physiological and behavioral circadian rhythms.
Purpose of the Study:
- To investigate circadian rhythmicity in human adipose tissue.
- To explore the relationship between the circadian system and obesity.
- To understand the concept of chronodisruption and its impact on health.
Main Methods:
- Utilized microarray studies to analyze gene expression.
- Investigated the presence of peripheral clocks in adipose tissue.
- Examined the interconnection between obesity and chronodisruption.
Main Results:
- Human adipose tissue exhibits circadian rhythmicity and possesses an internal peripheral clock.
- Chronodisruption is common in modern society due to factors like jet lag and shift work.
- Obesity and chronodisruption are demonstrated to be highly interconnected.
Conclusions:
- Chronobiology provides a new perspective on obesity, emphasizing the 'when' of factor production.
- Adipose tissue's circadian clock plays a role in metabolic regulation.
- Understanding chronodisruption is crucial for addressing obesity.
Related Concept Videos
02:19Circadian Rhythms and Gene Regulation
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
02:19Circadian Rhythms and Gene Regulation
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
01:24Obesity
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
02:45Biological Clocks and Seasonal Responses
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
01:15Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
01:20Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...