Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...

Drug Dosing: Obese Patients

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Metabolomic Insights Into the Impact of a Maternal Western-Style Diet and Leptin Supplementation During Suckling on Adult Rat Offspring.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026

Same author

Sex-Specific Lasting Metabolome Effects of Adverse Gestational Conditions and Prevention by Myo-Inositol Supplementation During Suckling.

Molecular nutrition & food research·2025

Same author

Interscapular white adipose tissue: An interesting depot for browning research in rodents.

The Journal of nutritional biochemistry·2025

Same author

Altered Hippocampal Transcriptomic Profile Reveals Cognitive Impairment in Young Metabolically Obese, Normal-Weight Rats, Prevented by Perinatal Leptin Intake.

Molecular nutrition & food research·2025

Same author

Myo-inositol supplementation in diet-induced obese lactating rats mitigates metabolic dysregulation and improves offspring health in early life.

The Journal of nutritional biochemistry·2025

Same author

Perinatal leptin effects on hypothalamic brain-derived neurotrophic factor and energy balance-related gene regulation.

The Journal of nutritional biochemistry·2025

Search research articles

Related Experiment Video

Updated: May 8, 2026

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

Challenges in obesity research.

Andreu Palou, M Luisa Bonet

Nutricion Hospitalaria

|September 10, 2013

Summary

Obesity is a major health issue driven by complex factors. Research explores new therapeutic targets like brown fat, genetics, and the microbiome to combat obesity effectively.

Area of Science:

Nutrition and metabolic disorders
Genetics and epigenetics
Environmental health

Background:

Obesity is a primary health concern in developed nations, stemming from multifaceted determinants.
Understanding obesity's causes is crucial for effective prevention and management strategies.
Interrelated socio-cultural, economic, behavioral, and biological factors contribute to obesity phenotypes.

Purpose of the Study:

To review current research challenges and emerging scientific approaches for obesity control.
To provide a comprehensive overview of advances and future directions in obesity research.
To inform stakeholders involved in understanding and combating obesity.

Main Methods:

Exploration of brown adipose tissue thermogenesis and white fat browning as therapeutic targets.

More Related Videos

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

Published on: November 11, 2025

Related Experiment Videos

Last Updated: May 8, 2026

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes

Published on: March 15, 2018

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

Development and Validation of a Methodology for Establishing Obese Rat Models with Typical Fatty Pancreas

Published on: November 11, 2025

Investigation of the roles of the microbiome, genetics, epigenetics, nutrigenomics, and nutrigenetics.

Analysis of food and lifestyle determinants, including neurobiological eating mechanisms and physical activity control.

Main Results:

Identified potential therapeutic targets in brown adipose tissue and fat browning.
Highlighted the significance of genetic, epigenetic, and microbiome influences on obesity.
Emphasized the impact of environmental factors, early nutrition, and lifestyle on obesity development.

Conclusions:

Emerging research offers novel therapeutic strategies for obesity management.
A holistic approach considering genetics, environment, and lifestyle is essential for combating obesity.
Continued research and interdisciplinary collaboration are vital for addressing the global obesity epidemic.