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Updated: May 8, 2026

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

Plasma adiponectin: a contributing factor for cardiac changes in visceral obesity-associated hypertension

Tiziana Di Chiara1, Anna Licata, Christiano Argano

  • 1Dipartimento Biomedico di Medicina Interna e Specialistica, University of Palermo , Palermo , Italy.

Blood Pressure
|September 10, 2013
PubMed

Insights

Adiponectin levels are lower in individuals with visceral obesity and hypertension. Lower adiponectin is linked to increased left ventricular mass, suggesting a key role in cardiac damage, especially in hypertensive patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Obesity Research

Background:

  • Visceral obesity is associated with hypertension and cardiac remodeling.
  • Adiponectin, an adipokine, plays a role in metabolic and cardiovascular health.
  • The specific impact of adiponectin on left ventricular geometry in obesity-associated hypertension requires further elucidation.

Purpose of the Study:

  • To evaluate the relationship between adiponectin levels and left ventricular geometry and function.
  • To investigate this relationship in subjects with visceral obesity-associated hypertension compared to lean controls.

Main Methods:

  • Study included 94 subjects (53 hypertensive, 41 normotensive), aged ≤65 years, stratified by visceral obesity.
  • Adiponectin levels were measured using radioimmunoassay.
  • Echocardiography and Doppler assessed left ventricular dimensions, mass (LVM/h(2.7)), and diastolic function.

Main Results:

  • Adiponectin levels were significantly lower in visceral obesity-associated hypertensives compared to lean hypertensives and normotensives.
  • Left ventricular mass (LVM/h(2.7)) was significantly higher in both hypertensive groups and in visceral obesity-associated normotensives.
  • Adiponectin inversely correlated with LVM/h(2.7) in visceral obese normotensive and hypertensive subjects, independent of other risk factors.

Conclusions:

  • Adiponectin plays a significant role in the increased left ventricular mass observed in visceral obesity, in both normotensive and hypertensive individuals.
  • In hypertensive subjects with visceral obesity, adiponectin levels may be a more critical determinant of cardiac damage than blood pressure itself.

Keywords:
Adiponectinleft ventricular massobesity-associated hypertension

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