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Updated: May 8, 2026

Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS
Published on: July 11, 2016
The predominant bacteria isolated from radicular cysts
Mustafa Tek1, Murat Metin, Ismail Sener
1Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Abant Izzet Baysal University, Bolu, Turkey. mtek@ibu.edu.tr.
Radicular cysts harbor diverse oral bacteria, with Streptococcus species, particularly the Streptococcus milleri Group, being most common. These inflammatory cysts often have polymicrobial origins but can occasionally be sterile.
Area of Science:
- Microbiology
- Oral Pathology
- Endodontics
Background:
- Radicular cysts are inflammatory jaw cysts originating from pulpal inflammation.
- Understanding the microbial etiology of radicular cysts is crucial for effective treatment and management.
Purpose of the Study:
- To identify the predominant bacteria associated with radicular cysts.
- To analyze the findings in the context of existing scientific literature.
Main Methods:
- Samples were collected from 35 radicular cysts via aspiration.
- Microbiologic analysis was performed using modern laboratory techniques.
Main Results:
- A wide range of anaerobic and facultative anaerobic bacteria were isolated.
- Streptococcus species were predominant (47.5%), with the Streptococcus milleri Group (SMG) being most frequent (23.8%).
- Common oral flora microorganisms were identified, suggesting a polymicrobial origin.
Conclusions:
- Radicular cysts exhibit a diverse bacterial flora, primarily composed of common oral microorganisms.
- While Streptococcus spp. were predominant, no single specific bacterium was exclusively linked to radicular cysts.
- Radicular cysts may arise from polymicrobial infections, though sterile cases are possible.
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