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Related Experiment Video

Updated: May 8, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

Cyclodextrin derivatives as anti-infectives.

Vladimir A Karginov¹

¹Innovative Biologics, Inc., 13455 Sunrise Valley Drive, Suite 200, Herndon, VA 20171, USA.

Current Opinion in Pharmacology

|September 10, 2013

Summary

Cyclodextrin derivatives show promise as anti-infectives by targeting bacterial pore-forming proteins. This approach successfully identified inhibitors for multiple dangerous bacterial toxins, paving the way for broad-spectrum drugs.

Area of Science:

Biochemistry
Microbiology
Medicinal Chemistry

Background:

Pore-forming proteins are crucial virulence factors for many bacterial pathogens.
Developing effective anti-infectives targeting these proteins is a significant challenge in combating infectious diseases.

Purpose of the Study:

To explore the potential of cyclodextrin (CD) derivatives as anti-infectives targeting bacterial pore-forming proteins.
To identify potent inhibitors of bacterial toxins using a library of CD derivatives.

Main Methods:

A library of approximately 200 per-substituted cyclodextrin derivatives was screened.
The selection strategy leveraged the symmetry matching between cyclodextrins and target protein pores.
Inhibitors were identified for toxins from Bacillus anthracis, Staphylococcus aureus, Clostridium perfringens, Clostridium botulinum, and Clostridium difficile.

Related Experiment Videos

Last Updated: May 8, 2026

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

Main Results:

Highly efficient selection of potent CD-based inhibitors was achieved.
The study identified multi-targeted inhibitors effective against a range of bacterial toxins.
The efficacy of CD derivatives against specific bacterial toxins was demonstrated.

Conclusions:

Per-substituted cyclodextrins are effective anti-infectives targeting bacterial pore-forming proteins.
This approach enables the discovery of multi-targeted inhibitors for various bacterial pathogens.
The findings support the development of novel, broad-spectrum anti-infective drugs.