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Updated: May 8, 2026

15N CPMG Relaxation Dispersion for the Investigation of Protein Conformational Dynamics on the µs-ms Timescale
Published on: April 19, 2021
Parallelizing acquisitions of solid-state NMR spectra with multi-channel probe and multi-receivers: applications to
Charlotte Martineau1, Frank Decker, Frank Engelke
1Tectospin, Institut Lavoisier de Versailles (ILV), UMR CNRS 8180, Université de Versailles Saint-Quentin-en-Yvelines, 45 Avenue des États-Unis, 78035 Versailles cedex, France.
Abstract:
A five-channel ((1)H, (19)F, (31)P, (27)Al, (13)C) 2.5 mm magic-angle-spinning (MAS) nuclear magnetic resonance (NMR) probe is used in combination with three separate receivers for the parallel acquisitions of one (1D) and two-dimensional (2D) NMR spectra in model fluorinated aluminophosphate and porous Al-based metal-organic framework (MOF). Possible combinations to record simultaneously spectra using this set-up are presented, including (i) parallel acquisitions of quantitative 1D NMR spectra of solids containing nuclei with contrasted T1 relaxation rates and (ii) parallel acquisitions of 2D heteronuclear NMR spectra. In solids containing numerous different NMR-accessible nuclei, the number of NMR experiments that have to be acquired to get accurate structural information is high. The strategy we present here, i.e. the multiplication of both the number of irradiation channels in the probe and the number of parallel receivers, offers one possibility to optimize this measurement time.
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