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Updated: Aug 7, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
[Primary nephrotic syndrome associated with renal tubular dysfunctions: renal morphologic alteration and response to
Abstract:
To evaluate the importance of renal tubular dysfunctions (RTD) in the patients with primary nephrotic syndrome (NS), renal tubular functions tests and renal biopsies were taken in 25 cases with NS. They were divided into two groups: A. with RTD (15 cases); B. without RTD (10 cases). Four glomerular pathological types were found in 22 cases: 15 cases with MePGN, 2 cases with IgAN, 4 cases with MPGN, 1 case with SGN. Degrees of pathological alteration of renal tubules were as follows: 5 cases in grade 0, all from group B. 11 cases in grade I, 7 belong to group A and 4 to group B. Each 3 cases in Grade II and grade III, all of them from group A. Treatment with steroids and cyclophosphane resulted in complete remission in 1 case and no effect in 11 cases of group A, and complete remission in 6 cases and no effect in 3 cases of group B. NS associated with RTD is common in adults, and its major clinical characteristic is resistant to steroid therapy. RTD is closely related to renal tubular morphological changes, and is not related to pathological classification of glomerular alteration.
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