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Updated: May 8, 2026
09:41
Functional Transcranial Doppler Ultrasound for Monitoring Cerebral Blood Flow
Published on: March 15, 2021
Functional imaging of cerebral perfusion.
A Krainik1, M Villien, I Troprès
1Clinique universitaire de neuroradiologie et IRM, CHU de Grenoble, CS 10217, 38043 Grenoble cedex, France; Inserm U836, université Joseph-Fourier, site santé, chemin Fortuné-Ferrini, 38706 La Tronche cedex, France; UMS IRMaGe, unité IRM 3T recherche, CHU de Grenoble, CS 10217, 38043 Grenoble cedex 9, France.
Diagnostic and Interventional Imaging
|September 10, 2013
Summary
Functional perfusion imaging studies blood flow regulation and neurovascular coupling. This technique assesses vascular reserve and ischemia risk, aiding therapeutic strategies for conditions like Alzheimer's disease and epilepsy.
Area of Science:
- Neuroimaging
- Medical Physics
- Cardiovascular Physiology
Background:
- Functional perfusion imaging offers insights into cerebrovascular dynamics.
- Understanding vasoreactivity, autoregulation, and neurovascular coupling is crucial for diagnosing neurological disorders.
Purpose of the Study:
- To explore the applications of functional perfusion imaging in studying hemodynamic disorders.
- To evaluate its role in assessing vascular reserve and ischemia risk.
- To enhance the interpretation of functional MRI in clinical research and practice.
Main Methods:
- Utilizing functional imaging techniques to assess perfusion.
- Analyzing vasoreactivity to circulating gases.
- Estimating vascular reserve downstream from arterial stenosis.
Main Results:
- Functional perfusion imaging reveals hemodynamic disorders in Alzheimer's disease and epilepsy patients with arteriovenous malformations.
- The method quantifies vasoreactivity, autoregulation, and neurovascular coupling.
- It aids in estimating vascular reserve and ischemia risk for therapeutic strategy adaptation.
Conclusions:
- Functional perfusion imaging is a valuable tool for studying cerebrovascular function.
- It aids in diagnosing and managing neurological conditions associated with hemodynamic dysfunction.
- This technique improves the interpretation of functional MRI findings in research and clinical settings.
Keywords:
ASLAutoregulationBOLDCBFCBVCVRCerebral perfusionCerebral vasoreactivityFunctional BOLD MRIMRANeurovascular couplingP(a)CO(2)P(e)CO(2)arterial pressure in CO(2)arterial spin labelingblood oxygenation level dependentcerebral blood flowcerebral blood volumecerebral vasoreactivityexpiratory pressure in CO(2)fMRIfunctional MRImagnetic resonance angiography
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