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Prevalence and determinants of elevated high-sensitivity cardiac troponin T in hypertrophic cardiomyopathy

Yaser Jenab1, Marzieh Pourjafari1, Farzad Darabi1

  • 1Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.

Journal of Cardiology
|September 10, 2013
PubMed

Insights

Increased high-sensitivity cardiac troponin T (hs-cTnT) is common in hypertrophic cardiomyopathy (HCM). Age, LV wall thickness, LA area index, and E/Ea septal are key determinants of elevated hs-cTnT, indicating myocardial injury.

Area of Science:

  • Cardiology
  • Biomarkers
  • Cardiovascular Disease

Background:

  • Hypertrophic cardiomyopathy (HCM) is a complex cardiac condition.
  • Cardiac injury assessment in HCM is crucial for patient management.
  • High-sensitivity cardiac troponin T (hs-cTnT) is a sensitive biomarker for myocardial injury.

Purpose of the Study:

  • To determine the prevalence of elevated hs-cTnT in patients with HCM.
  • To identify clinical and echocardiographic determinants of increased hs-cTnT in HCM.
  • To evaluate hs-cTnT as a marker of cardiac injury in HCM.

Main Methods:

  • A cohort of 98 consecutive HCM patients was assessed.
  • Serum hs-cTnT levels were measured alongside clinical evaluations.
  • Echocardiography and Holter monitoring were performed.

Main Results:

  • 42.9% of HCM patients had hs-cTnT levels ≥ 14 ng/L.
  • Elevated hs-cTnT correlated with chest pain, LV hypertrophy, and ventricular arrhythmias.
  • Independent determinants of elevated hs-cTnT included age, LV wall thickness, LA area index, and E/Ea septal.

Conclusions:

  • Elevated hs-cTnT is prevalent in HCM patients.
  • hs-cTnT serves as a valuable indicator of myocardial injury in HCM.
  • Further research can explore hs-cTnT's prognostic role in HCM.
Abstract

Keywords:
EchocardiographyEjection fractionHypertrophic cardiomyopathyTroponin

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