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Related Experiment Videos

[Problems with malachite green use in fish].

M Kietzmann1, H J Hapke, M Beeke

  • 1Institut für Pharmakologie, Toxikologie und Pharmazie der Tierärztlichen Hochschule Hannover.

DTW. Deutsche Tierarztliche Wochenschrift
|July 1, 1990
PubMed
Summary

Malachite green oxalate treats fish diseases but is not licensed in Germany. Due to slow elimination in trout and carp, a long withdrawal time is crucial to meet low tolerance limits.

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Area of Science:

  • Veterinary Pharmacology
  • Aquatic Toxicology
  • Food Safety

Context:

  • Malachite green oxalate is a widely used antimycotic and antiparasitic agent in aquaculture for treating fish diseases.
  • Its therapeutic use is not currently licensed under the German drug act, necessitating regulatory attention.
  • A decree establishes a strict tolerance limit of 0.01 mg malachite green per kilogram of fish-derived food products.

Purpose:

  • To address the regulatory status and therapeutic application of malachite green oxalate in fish treatment.
  • To highlight the slow elimination kinetics of malachite green in key aquaculture species like trout and carp.
  • To emphasize the importance of considering toxicology and low tolerance levels for safe fish consumption.

Summary:

  • Malachite green oxalate, an arylmethane dye, is employed for its antimycotic and antiparasitic properties in managing fish diseases.
  • Despite its use, regulatory approval in Germany is pending, with a defined tolerance limit for food products.
  • The slow metabolic clearance of malachite green in trout and carp necessitates extended withdrawal periods to ensure food safety.

Impact:

  • Informs regulatory bodies and aquaculturists about the implications of malachite green use in fish farming.
  • Underscores the need for adherence to strict withdrawal times to prevent residues in food products.
  • Contributes to the ongoing discussion regarding the safe and regulated use of therapeutic agents in aquaculture.

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