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Neurocognition in early-onset schizophrenia
1Department of Psychiatry, Icahn School of Medicine at Mount Sinai, Box 1230, 1425 Madison Avenue, New York, NY 10029, USA.
Child and Adolescent Psychiatric Clinics of North America
|September 10, 2013
Summary
Early-onset schizophrenia (EOS) involves severe cognitive impairments affecting cognitive development. This review synthesizes data on the profile, severity, and progression of these cognitive deficits in EOS patients.
Area of Science:
- Neuroscience
- Psychiatry
- Developmental Psychology
Background:
- Cognitive impairment is a core feature of schizophrenia.
- Early-onset schizophrenia (EOS) is a severe form with childhood/adolescent onset.
- Studying EOS offers insights into disease mechanisms impacting cognitive development.
Purpose of the Study:
- To summarize and synthesize data on cognitive impairments in EOS.
- To detail the profile and severity of these impairments.
- To examine the evolution of cognitive deficits over time in EOS.
Main Methods:
- Literature review and data synthesis.
- Analysis of existing research on cognitive function in EOS.
- Comparative analysis of cognitive profiles.
Main Results:
- EOS is characterized by significant and pervasive cognitive deficits.
- Impairments are present early and may worsen over time.
- Specific cognitive domains affected include memory, attention, and executive functions.
Conclusions:
- Cognitive abnormalities are central to the pathophysiology of EOS.
- Understanding cognitive evolution in EOS is crucial for intervention.
- Further research is needed to elucidate underlying mechanisms and guide treatment.
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