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Pediatric asthma evaluation: what's to be considered?

Marcello Verini1, Giancarlo Tancredi, Enrico Lombardi

  • 1Department of Pediatric, Clinical Hospital and Pediatric School of Medicine, University "G. D'Annunzio", Chieti, Italy.

Early Human Development
|September 10, 2013
PubMed

Insights

Identifying early childhood asthma requires effective outcome measures. Current methods like questionnaires and lung function tests assess damage but no single measure captures the full impact of asthma on children and families.

Area of Science:

  • Pediatrics
  • Pulmonology
  • Clinical Research

Background:

  • Asthma often originates in early childhood, necessitating sensitive outcome measures for research and clinical use.
  • Existing assessment tools include clinical questionnaires, pulmonary function tests, airway reactivity tests, and inflammation markers.

Purpose of the Study:

  • To review current outcome measures for early childhood asthma.
  • To highlight the limitations of existing methods in comprehensively evaluating asthma's multifaceted impact.

Main Methods:

  • Literature review of established asthma assessment tools.
  • Analysis of the applicability and limitations of various outcome measures across different age groups.

Main Results:

  • Questionnaires like ISAAC, Asthma Control Test, and Health Related Quality of Life are widely used.
  • Pulmonary function tests are broadly applicable, but airway responsiveness testing is limited to school-aged children.
  • Exhaled nitric oxide is the primary useful measure for respiratory inflammation.

Conclusions:

  • The complex pathophysiology of asthma and its broad effects necessitate a multi-dimensional approach to outcome measurement.
  • No single existing measure can simultaneously assess all aspects of asthma, including molecular, cellular, inflammatory, functional, and quality-of-life impacts.

Keywords:
Airways responsivenessChildhood asthmaExhaled nitric oxideOutcome measuresRespiratory function tests

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