Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Effects of Radiation02:59

Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they produce ions...
Radiation: Applications01:17

Radiation: Applications

The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Mutations01:35

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Absorption of Radiation01:05

Absorption of Radiation

The rate of heat transfer by emitted radiation is described by the Stefan-Boltzmann law of radiation:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cutaneous T-cell lymphoma tumors undergoing radiotherapy demonstrate immune shifts from malignant inflammation to wound healing and suggest markers of treatment durability.

Journal of the American Academy of Dermatology·2026
Same author

Radiation Oncology-Biology Integration Network: Bridging the Gap between Biological Research and Clinical Practice.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026
Same author

m <sup>6</sup> A-dependent microRNA binding to chromatin-associated RNA for transcriptional activation.

bioRxiv : the preprint server for biology·2026
Same author

The OligoPanc project: an interdisciplinary expert consensus statement on oligometastatic pancreatic cancer.

The Lancet. Oncology·2026
Same author

IFN signaling at the nexus of the radiotherapy response in malignant peripheral nerve sheath tumors.

The Journal of clinical investigation·2026
Same author

Spatial Confinement of Platinum Nanoclusters in a Photoactive Metal-Organic Framework for Radiotherapy Enhancement and Redox-Mediated Immune Activation.

Journal of the American Chemical Society·2026
Same journal

Integrative Medicine for Breast Cancer Survivors.

Seminars in radiation oncology·2026
Same journal

Integrative Oncology Approaches for Gastrointestinal Symptoms and Risk Reduction in Patients With Digestive Tract Cancers.

Seminars in radiation oncology·2026
Same journal

Integrative Oncology and Radiation Therapy: An Essential Evolution.

Seminars in radiation oncology·2026
Same journal

Clinical Trials of Integrative Oncology Interventions for Radiation Therapy: Emerging Evidence and Opportunities.

Seminars in radiation oncology·2026
Same journal

Nonpharmacologic Approaches for Pain Management in Patients With Cancer Treated With Radiation Therapy.

Seminars in radiation oncology·2026
Same journal

Integrative Therapies for Radiation-Related Toxicities in Hematological Malignancies.

Seminars in radiation oncology·2026
See all related articles

Related Experiment Video

Updated: May 8, 2026

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
09:04

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

Radiation as an immune modulator.

Byron Burnette1, Ralph R Weichselbaum

  • 1Department of Radiation and Cellular Oncology, The Ludwig Center for Metastasis Research, The University of Chicago, Chicago, IL.

Seminars in Radiation Oncology
|September 10, 2013
PubMed
Summary
This summary is machine-generated.

Radiation therapy, a key cancer treatment, works by damaging cancer cell DNA. Emerging research highlights its complex interplay with inflammation and the tumor microenvironment, influencing treatment outcomes.

More Related Videos

A Co-culture Method to Investigate the Crosstalk Between X-ray Irradiated Caco-2 Cells and PBMC
11:40

A Co-culture Method to Investigate the Crosstalk Between X-ray Irradiated Caco-2 Cells and PBMC

Published on: January 30, 2018

Related Experiment Videos

Last Updated: May 8, 2026

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
09:04

Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells

Published on: March 7, 2025

A Co-culture Method to Investigate the Crosstalk Between X-ray Irradiated Caco-2 Cells and PBMC
11:40

A Co-culture Method to Investigate the Crosstalk Between X-ray Irradiated Caco-2 Cells and PBMC

Published on: January 30, 2018

Area of Science:

  • Oncology
  • Immunology
  • Radiation Biology

Background:

  • Radiation therapy is a cornerstone of cancer treatment, primarily acting by inducing DNA damage in cancer cells.
  • Recent advancements have broadened the understanding of radiation's effects, including cell death mechanisms and regulatory pathways.
  • The role of inflammation in cancer progression and its interaction with radiation therapy are areas of active investigation.

Purpose of the Study:

  • To review the immunostimulatory effects of radiation therapy.
  • To explore the impact of radiation therapy on the tumor microenvironment.
  • To discuss the dual role of inflammation in cancer and its modulation by radiation.

Main Methods:

  • Literature review of radiation therapy mechanisms.
  • Analysis of studies on radiation-induced cell death.
  • Examination of research on inflammation and the tumor microenvironment.

Main Results:

  • Radiation therapy induces cancer cell death via DNA double-strand breaks.
  • Inflammation can promote or inhibit tumor growth and response to therapy.
  • Radiation therapy can modulate the tumor microenvironment, potentially enhancing anti-tumor immunity.

Conclusions:

  • Radiation therapy's effects extend beyond direct tumor cell killing.
  • The interplay between radiation, inflammation, and the tumor microenvironment is critical for treatment efficacy.
  • Further research into these interactions may lead to improved cancer treatment strategies.