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Changes in plasma adipokines in prepubertal children with a history of extrauterine growth restriction

María Ortiz-Espejo1, Juan Luís Pérez-Navero, Josune Olza

  • 1Unit of Metabolism and Pediatric Investigation, Department of Pediatrics, University Reina Sofia Hospital, Córdoba, Spain.

Nutrition (Burbank, Los Angeles County, Calif.)
|September 10, 2013
PubMed

Insights

Children with extrauterine growth restriction (EUGR) show altered adipokine levels, with lower adiponectin and higher resistin. These early changes in adipokines may indicate future metabolic syndrome or cardiovascular disease risk.

Area of Science:

  • Pediatric Endocrinology
  • Metabolic Research
  • Nutritional Science

Background:

  • Nutritional support during perinatal life influences metabolic programming.
  • Extrauterine growth restriction (EUGR) may lead to alterations in adipocyte function and adipokine secretion.
  • Adipokines play a crucial role in regulating metabolism and energy balance.

Purpose of the Study:

  • To assess adiponectin, resistin, and leptin concentrations in prepubertal children with a history of EUGR.
  • To determine the correlation between these adipokines and metabolic parameters in children with EUGR.
  • To investigate potential long-term metabolic consequences of early postnatal malnutrition.

Main Methods:

  • A case-control study involving 38 prepubertal children with EUGR and 123 healthy controls.
  • Assessment of anthropometric measures, blood pressure, and biochemical markers.
  • Evaluation of plasma concentrations of adiponectin, resistin, and leptin.

Main Results:

  • Children with EUGR exhibited significantly lower adiponectin and higher resistin levels compared to controls, even after adjustments.
  • Systolic blood pressure in the EUGR group was associated with adipokine concentrations.
  • Adiponectin correlated with high-density lipoprotein cholesterol, and resistin with carbohydrate metabolism parameters in EUGR children.

Conclusions:

  • Early postnatal malnutrition in EUGR children may program adipose tissue development and function.
  • Plasma adipokine measurements in childhood can identify precocious metabolic changes.
  • These findings suggest a potential increased risk for metabolic syndrome and cardiovascular disease later in life for children with EUGR.
Abstract

Keywords:
AdipokinesAdiponectinMalnutritionPrepubertalPretermResistin

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