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Related Experiment Videos

Translational research in endocrine surgery.

Scott K Sherman1, James R Howe

  • 1Department of Surgery, Carver College of Medicine, The University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA.

Surgical Oncology Clinics of North America
|September 10, 2013
PubMed
Summary

Translational research in endocrine surgery advances treatment for thyroid, parathyroid, adrenal, and pancreatic disorders. Basic science discoveries are improving surgical options and patient care for endocrine cancers.

Related Concept Videos

Endocrine Signaling01:45

Endocrine Signaling

Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.

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Area of Science:

  • Endocrine Surgery
  • Translational Research
  • Oncology

Background:

  • Endocrine surgery addresses disorders of the thyroid, parathyroids, adrenals, and endocrine pancreas.
  • Heritable endocrine cancer syndromes and sporadic endocrine cancers present significant clinical challenges.

Purpose of the Study:

  • To review translational research impacting endocrine surgery.
  • To highlight how basic science discoveries are refining surgical treatments and patient care.

Main Methods:

  • Review of current literature on translational research in endocrine surgery.
  • Focus on genetic discoveries and their clinical applications.

Main Results:

  • Gene discoveries for heritable endocrine cancers enhance understanding of mechanisms and surgical options.
Keywords:
Endocrine cancerHeritable cancer syndromesMEN2Pancreatic neuroendocrine tumorsThyroid surgery

Related Experiment Videos

  • Mutation knowledge in sporadic cancers drives progress in small-molecule kinase inhibitor therapies.

    • Conclusions:

    • Basic science research is crucial for developing new clinical treatments in endocrine surgery.
    • Advances in understanding endocrine cancer genetics are improving surgical strategies and patient outcomes.