Related Experiment Video

Updated: Feb 7, 2026

Manufacture of a Multi-Purpose Low-Cost Animal Bench-Model for Teaching Tracheostomy
10:06

Manufacture of a Multi-Purpose Low-Cost Animal Bench-Model for Teaching Tracheostomy

Published on: May 18, 2019

6.0K

Getting from the bench to the patient: biotechnology strategies

Hagop Youssoufian1, Jonathan Lewis

  • 1One First Avenue, Parris Building 34, Navy Yard Plaza, Boston, MA 02129, USA.

Surgical Oncology Clinics of North America
|September 10, 2013
PubMed

Insights

This study explores cancer therapeutics, focusing on palifosfamide drug development and synthetic biology applications. It highlights advances in oncology drug discovery and gene therapy for improved patient outcomes.

Area of Science:

  • Biotechnology
  • Oncology
  • Translational Research

Background:

  • Drug development is inefficient despite molecular pathobiology advances.
  • Translational research aims to bridge scientific discovery and clinical application.
  • Cancer therapeutics face challenges in adopting new knowledge.

Purpose of the Study:

  • To highlight advances in oncology drug development.
  • To showcase the application of synthetic biology in cancer treatment.
  • To discuss the optimization of novel cancer therapeutics.

Main Methods:

  • Optimizing safety and efficacy of palifosfamide, a novel DNA cross-linking small molecule.
  • Implementing synthetic biology for clinical practice via gene therapy.
  • Utilizing intratumorally injected interleukin-12 DNA (a potent cytokine).

Main Results:

  • Palifosfamide shows promise as a novel DNA cross-linking agent.
  • Synthetic biology approaches are being integrated into clinical practice.
  • Interleukin-12 DNA gene therapy demonstrates potential in oncology.

Conclusions:

  • Biotechnology organizations are making significant strides in cancer therapeutics.
  • Translational research is key to improving the efficiency of drug development.
  • Novel approaches like gene therapy and optimized small molecules offer new hope for cancer treatment.
Keywords:
BiotechnologyImmunotherapyPalifosfamideSynthetic biologyTranslational research

More Related Videos

Analysis of Fucosylated Human Milk Trisaccharides in Biotechnological Context Using Genetically Encoded Biosensors10:17

Analysis of Fucosylated Human Milk Trisaccharides in Biotechnological Context Using Genetically Encoded Biosensors

Published on: April 13, 2019

6.8K
A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

26.5K

Related Concept Videos

Strategies of Self-Presentation II: Self-Verification01:17

Strategies of Self-Presentation II: Self-Verification

Self-verification is a fundamental psychological drive wherein individuals seek affirmation of their self-concept from others, striving for consistency between their internal self-view and external perceptions. This drive operates even when the self-concept is negative, influencing interpersonal behavior and feedback preferences in complex and often counterintuitive ways. Unlike the self-enhancement motive, which seeks positive evaluations, self-verification prioritizes coherence and...
193
Plant Breeding and Biotechnology01:59

Plant Breeding and Biotechnology

Crop cultivation has a long history in human civilization, with records showing the cultivation of cereal plants beginning at around 8000 BC. This early plant breeding was developed primarily to provide a steady supply of food.
21.8K
Persuasion Strategies01:52

Persuasion Strategies

Researchers have tested many persuasion strategies, including the foot-in-the door and the door-in-the-face techniques, in a variety of contexts. Ultimately, the principles are effective in selling products and changing people’s attitude, ideas, and behaviors (Cialdini & Goldstein, 2004).
43.5K
Coping Strategies: Problem Focused01:27

Coping Strategies: Problem Focused

Coping strategies are methods people use to manage, tolerate, or reduce the effects of stressors. These strategies involve both behavioral and psychological actions to handle stressful situations. One common approach is problem-focused coping, which aims to change or eliminate the source of stress rather than merely addressing its consequences. This method involves taking direct action to resolve the issue causing stress.
For example, consider a student who struggles to understand their...
522
Guidelines and Strategies for Safe Computer Charting01:18

Guidelines and Strategies for Safe Computer Charting

The guidelines and strategies provided by the American Nurses Association (ANA) and the Canadian Nurses Association (CNA) offer essential principles for ensuring safe and secure computer charting systems in healthcare settings. Let's break down each recommendation:
Maintain Confidentiality and Security:
2.7K
Coping Strategies: Emotion Focused01:20

Coping Strategies: Emotion Focused

Emotion-focused coping refers to a set of strategies aimed at managing the emotional impact of stressors, rather than directly addressing their causes. This approach involves altering one's emotional response to stressful situations to reduce their psychological effects. For example, individuals might talk with a friend or engage in activities like journaling to express their feelings. Such actions can help achieve emotional clarity or release, providing the psychological stability needed...
534