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Localized argyria caused by metallic silver aortic grafts: a unique adverse effect
P Berger1, J B Ricco, P Liqui Lung
1Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.
Summary
Two patients experienced localized argyria, a rare adverse effect, after receiving silver-coated vascular grafts. This suggests a potential toxicity risk from silver in vascular implants.
Area of Science:
- Vascular Surgery
- Toxicology
- Biomaterials Science
Background:
- Silver-coated grafts are utilized to prevent vascular graft infections.
- While silver is generally considered safe, toxic effects have been documented.
- This study investigates potential adverse reactions to silver grafts.
Observation:
- Two patients developed groin collections post-silver graft implantation.
- During surgery, an ashen-grey, necrotic substance was observed around the grafts.
- Grafts were removed, and lower limb perfusion was re-established.
Findings:
- Histological examination revealed localized silver toxicity.
- Neutrophilic-mediated tissue destruction was also identified.
- Cultures from the surgical site were negative for infection.
Implications:
- These cases suggest a unique adverse effect of localized silver toxicity combined with tissue destruction.
- This highlights a potential risk associated with silver-containing vascular grafts.
- Further research is needed to understand and mitigate these adverse effects.
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