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Published on: May 14, 2013
Localized argyria caused by metallic silver aortic grafts: a unique adverse effect
P Berger1, J B Ricco, P Liqui Lung
1Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.
Introduction:
Silver-coated grafts are designed to prevent vascular graft infections. Silver is a safe element but toxic effects have been reported. We describe two cases of possible localized argyria after silver graft implantation.
Report:
Two patients presented with perigraft groin collections after implantation of silver grafts. During reoperation, an ashen-grey necrotic substance was seen surrounding the grafts. The grafts were explanted and lower limb perfusion restored. Cultures were negative and both patients had uneventful recoveries.
Discussion:
Our cases are highly suggestive of a possible unique adverse effect: a combination of localized silver toxicity and neutrophilic mediated tissue destruction.
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