Related Experiment Video
Updated: May 8, 2026

Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality
Published on: April 7, 2023
Characterization and performance assessment of solid dispersions prepared by hot melt extrusion and spray drying
Anjali M Agrawal1, Mayur S Dudhedia, Ashwinkumar D Patel
1Boehringer Ingelheim Pharmaceuticals Inc., 900 Ridgebury Road, Ridgefield, CT 06877, United States.
Abstract:
The present study investigated effect of manufacturing methods such as hot melt extrusion (HME) and spray drying (SD) on physicochemical properties, manufacturability, physical stability and product performance of solid dispersion. Solid dispersions of compound X and PVP VA64 (1:2) when prepared by SD and HME process were amorphous by polarized light microscopy, powder X-ray diffractometry, and modulated differential scanning calorimetry analyses with a single glass transition temperature. Fourier transform infrared (FT-IR) and Raman spectroscopic analyses revealed similar molecular level interactions between compound X and PVP VA64 as evident by overlapping FT-IR and FT Raman spectra in SD and HME solid dispersions. The compactibility, tabletability, disintegration and dissolution performance were similar for solid dispersions prepared by both processing techniques. Differences in material properties such as surface area, morphological structure, powder densities, and flow characteristics were observed between SD and HME solid dispersion. The SD solid dispersion was physically less stable compared to HME solid dispersion under accelerated stability conditions. Findings from this study suggest that similar product performance could be obtained if the molecular properties of the solid dispersion processed by two different techniques are similar. However differences in material properties might affect the physical stability of the solid dispersions.
More Related Videos
08:42Challenges in Rheological Characterization of Highly Concentrated Suspensions — A Case Study for Screen-printing Silver Pastes
Published on: April 10, 2017
11:27A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
Published on: August 9, 2022
Related Concept Videos
Factors Influencing Drug Absorption: Pharmaceutical Parameters
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence
Drug Dissolution: Requirements and Profile Comparison
Factors Affecting Dissolution: Particle Size and Effective Surface Area
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules
Bioavailability Enhancement: Drug Solubility Enhancement