Related Experiment Video
Updated: May 8, 2026
A Neonatal Mouse Spinal Cord Compression Injury Model
Published on: March 27, 2016
Experimental models of spinal open neural tube defect and Chiari type II malformation
Ki-Bum Sim1, Ji Yeoun Lee, Ji Hoon Phi
1Department of Neurosurgery, Jeju National University College of Medicine, Jeju, South Korea.
Introduction:
Experimental animal models are essential for investigation of the pathoembryogenesis, pathophysiology, and management strategy of spinal open neural tube defect (ONTD) and its associated anomalies including Chiari type II malformation. Genetic, chemical/nutrient, and surgical models have been widely used for a variety of purposes. The aim of this article is to review the representative animal models of spinal ONTD and associated Chiari type II malformation with respect to their advantages and disadvantages.
Discussion:
Among them, the surgical model was described in detail because it is familiar to neurosurgeons and it is used for evaluations of prenatal repair of spinal ONTDs. The surgical model also has advantages because it allows quantitative analysis of the lesions. A description of our previous studies on spinal ONTDs using a chick surgical model is presented as an example.
