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Pi trapping in glycogenolytic pathway can explain transient Pi disappearance during recovery from muscular exercise.
D Bendahan1, S Confort-Gouny, G Kozak-Reiss
1Centre de Résonance Magnétique Biologique et Médicale, Faculté de Médecine de Marseille, France.
Abstract:
31P NMR spectroscopy at 4.7 T has been used to follow changes in phosphorylated metabolites and pHi in the flexor digitorum superficialis muscle of 15 healthy volunteers subjected to a rest-exercise-recovery protocol. Phosphomonoesters (Pme) increased during exercise and exhibited a delayed recovery to resting level. During early recovery, Pi fell below resting concentration without correlated PCr oversynthesis while Pme level stayed above its resting value. The sum Pi + Pme remained constant. These observations suggest that Pi could be trapped into the glycogenolytic pathway during exercise leading to Pme production. This trapping and the slow Pme recovery could account for transient Pi disappearance observed during recovery.