Structure-based gene targeting discovery of sphaerimicin, a bacterial translocase I inhibitor
Masanori Funabashi1, Satoshi Baba, Toshio Takatsu
1Natural Product Research Group, Discovery Science and Technology Department, Drug Discovery and Biomedical Technology Unit, Daiichi Sankyo RD Novare Co., Ltd. Tokyo 134-8630 (Japan).
Angewandte Chemie (International Ed. in English)
|September 10, 2013
Abstract:
Rise and shine: Using a gene-targeting approach aimed at identifying potential L-threonine:uridine-5'-transaldolases that catalyze the formation of (5'S,6'S)-C-glycyluridine, a new bacterial translocase I inhibitor was discovered from an actinomycete following fermentation optimization.
Keywords:
actinomycetesbacterial translocase I inhibitorgene targetingnucleoside antibioticstransaldolase

