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Related Experiment Videos

Cellular adhesiveness on implanted lenses in monkeys.

T Ishibashi1, S Sugai, T Kubota

  • 1Department of Ophthalmology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|January 1, 1990
PubMed
Summary

Cellular adhesiveness on intraocular lenses (IOLs) involves macrophages and multinucleated giant cells. Microfilaments within these cells appear crucial for their attachment to implanted IOLs.

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Area of Science:

  • Ophthalmology
  • Cell Biology
  • Biomaterials Science

Background:

  • Cell adhesion to implanted intraocular lenses (IOLs) is a known phenomenon.
  • The specific mechanisms driving this cellular adhesiveness remain largely unknown.

Purpose of the Study:

  • To investigate the cellular mechanisms underlying adhesion to posterior chamber intraocular lenses (IOLs) after implantation.
  • To identify the types of cells and cellular structures involved in IOL surface attachment.

Main Methods:

  • Transmission electron microscopy (TEM) was used to examine IOLs explanted from monkey eyes.
  • IOLs were analyzed at 4 and 7 days post-implantation.

Main Results:

  • Macrophages were observed attached to IOL surfaces at 4 days post-implantation.

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  • Multinucleated giant cells were present on IOL surfaces at 7 days post-implantation.
  • These giant cells exhibited subplasmalemmal microfilament bundles in areas of close apposition to the IOL.

    • Conclusions:

    • Cellular adhesion to implanted IOLs involves sequential colonization by macrophages and multinucleated giant cells.
    • The presence of microfilaments suggests an active role in the cell-IOL adhesion process.