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Urinary 6-sulphatoxymelatonin levels and sleep disorders in children with migraine

Maha K Abou-Khadra1, Nirmeen A Kishk2, Olfat G Shaker3

  • 1Department of Pediatrics, Faculty of Medicine, Cairo University, Egypt maha_korany71@yahoo.com.

Journal of Child Neurology
|September 10, 2013
PubMed

Insights

Melatonin secretion is normal in children with migraine. However, sleep disturbances like bedtime resistance and parasomnias significantly worsen migraine disability in this pediatric group.

Area of Science:

  • Pediatric Neurology
  • Sleep Medicine
  • Chronobiology

Background:

  • Migraine is a common neurological disorder in children.
  • Sleep disturbances are frequently reported in children with migraine, but their relationship with melatonin secretion and migraine disability remains unclear.

Purpose of the Study:

  • To investigate melatonin secretion in children with migraine.
  • To characterize sleep patterns and problems in pediatric migraine patients.
  • To examine the association between sleep issues and migraine disability.

Main Methods:

  • Assessed urinary 6-sulphatoxymelatonin levels using ELISA in 18 children with migraine and 18 healthy controls.
  • Administered the Children's Sleep Habits Questionnaire and Pediatric Migraine Disability Assessment Score to parents.
  • Analyzed correlations between sleep parameters and migraine disability.

Main Results:

  • No significant differences in urinary 6-sulphatoxymelatonin levels were found between children with migraine and controls.
  • No significant differences in overall sleep habits were observed between the groups.
  • Significant correlations were identified between bedtime resistance, parasomnias, and increased migraine disability.

Conclusions:

  • Nocturnal melatonin production is not reduced in children experiencing migraine.
  • Sleep disturbances, particularly bedtime resistance and parasomnias, are linked to greater migraine disability in children.
  • Addressing sleep problems may be a crucial component in managing migraine in pediatric populations.

Keywords:
6-sulphatoxymelatoninmigrainesleep

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