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A Pipeline to Characterize Structural Heart Defects in the Fetal Mouse
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Published on: December 16, 2022

Cardiac outflow tract anomalies.

Zachary Neeb1, Jacquelyn D Lajiness, Esther Bolanis

  • 1Developmental Biology and Neonatal Medicine Program, HB Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

Wiley Interdisciplinary Reviews. Developmental Biology
|September 10, 2013
PubMed
Summary
This summary is machine-generated.

Congenital heart defects often involve the outflow tract (OFT). This review details how second heart field (SHF) and cardiac neural crest (CNC) cells independently shape the OFP, clarifying their roles in development and disease.

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Area of Science:

  • Developmental Biology
  • Cardiovascular Science
  • Genetics

Background:

  • The outflow tract (OFT) is a critical connection between heart chambers and embryonic vasculature.
  • Congenital heart defects (CHDs) frequently involve the OFT, highlighting its developmental importance.
  • Understanding OFT morphogenesis is key to addressing multifactorial CHDs.

Purpose of the Study:

  • To review the molecular and cellular mechanisms controlling OFT morphogenesis.
  • To elucidate the distinct contributions of second heart field (SHF) and cardiac neural crest (CNC) lineages to OFT development.
  • To explore the complex interactions between progenitor populations during OFT formation.

Main Methods:

  • Analysis of various animal models.
  • Human genetic investigations.
  • Review of current literature on OFT development and pathogenesis.

Main Results:

  • Established roles for SHF and CNC derivatives in OFT formation and remodeling.
  • Demonstrated that OFT alignment and septation are independent processes.
  • Identified separate SHF and CNC lineages contributing to OFT alignment and septation.

Conclusions:

  • The development of the outflow tract involves intricate interactions between progenitor populations.
  • SHF and CNC lineages play distinct and crucial roles in OFT development and septation.
  • Further research is needed to fully elucidate spatiotemporal cell lineage interactions and underlying pathogenesis in OFT development.