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Related Experiment Videos

Amiodarone-induced changes in lipid metabolism.

S E Kasim1, N Bagchi, T R Brown

  • 1Harper Hospital, Wayne State University, Detroit, Michigan.

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|July 1, 1990
PubMed
Summary

Amiodarone increases harmful cholesterol and apolipoprotein B, similar to hypothyroidism, but affects lipoprotein lipase differently. These lipid changes are not solely due to altered thyroid hormone levels.

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Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Background:

  • Hypothyroidism is a primary cause of secondary hypercholesterolemia.
  • Amiodarone, an antiarrhythmic drug, is known to affect both serum lipid and thyroid hormone levels.

Purpose of the Study:

  • To investigate the relationship between amiodarone-induced alterations in lipid metabolism and changes in thyroid hormone levels.
  • To determine if amiodarone's effects on lipids are solely explained by its impact on thyroid hormones.

Main Methods:

  • Eighteen patients were administered amiodarone for six weeks.
  • Evaluated serum lipids (triglycerides, total cholesterol, HDL-C, subfractions), apolipoproteins (A-I, B), and lipase activities (post-heparin LPL, hepatic TG lipase).
  • Measured serum thyroxine levels before and after treatment.

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Main Results:

  • Amiodarone significantly increased total cholesterol, LDL-C, and apolipoprotein B.
  • Serum HDL-C, its subfractions, and apolipoprotein A-I remained unchanged.
  • Post-heparin lipoprotein lipase activity increased, while hepatic triglyceride lipase activity showed no significant change.
  • Serum thyroxine levels increased but remained within the euthyroid range.

Conclusions:

  • Amiodarone therapy elevates atherogenic lipoproteins, mirroring effects seen in hypothyroidism.
  • The drug's impact on lipoprotein lipase activity contrasts with that observed in hypothyroidism.
  • Amiodarone-induced lipid metabolism changes cannot be attributed solely to alterations in circulating thyroid hormone levels.