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Interesting case of G6PD deficiency anemia with severe hemolysis

Anupam Chhabra1, David Raj, Pankaj N Choudhary

  • 1Department of Transfusion Medicine, Pushpanjali Crosslay Hospital, Ghaziabad, India.

Asian Journal of Transfusion Science
|September 10, 2013
PubMed

Severe hemolysis was observed in a critically ill patient with G6Pd deficiency where the causative trigger could not be identified. We describe one young patient with severe hemolysis treated with two cycles of plasmapheresis which proved to be an effective tool in the treatment. The patient presented with diffuse pain abdomen, vomiting, yellowish discoloration of sclera and skin and acute breathlessness. Hemoglobin 5.4 mg/dl and total (T) serum bilirubin 17.08 mg/dl: Direct (D) 4.10 mg/dl and Indirect (I) 12.98 mg/dl. Subsequently patient started passing black color urine. As the patient developed severe hemolysis and the trigger agent of hemolysis was unknown, two cycles of plasmapheresis were performed with the aim to remove unknown causative agent. Consequently no trace of hemolysis was found and patient stabilized. Plasmapheresis can be used to treat G6PD deficient patients with severe hemolysis due to unidentified trigger agent.

Keywords:
Acute hemolytic anemiaGlucose-6-phosphate dehydrogenase deficiencyplasmapheresistherapeutic plasma exchange

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