Related Experiment Video
Updated: May 8, 2026

Analysis of Developing Tooth Germ Innervation Using Microfluidic Co-culture Devices
Published on: August 14, 2015
Maturogenesis of non-vital immature permanent teeth
Ritesh R Kalaskar1, Ashita R Kalaskar
1Department of Pedodontics, Government Dental College and Hospital, Nagpur, Maharashtra, India.
Abstract:
Pulpal necrosis in young permanent teeth often results in teeth with open apex, thin root walls and poor crown root ratio. Out of the available treatment options maturogenesis has been the most conservative option that exploits full potential of pulp for dentin deposition. Maturogenesis involves disinfecting the root canal system followed by stimulation of blood clot from the periapical tissue, which provides a matrix into which the cell could grow and sealing the coronal excess. In the present case report, tri antibacterial paste (3 Mix) was used as an intracanal medicament that proved successful in stimulating vital pulp cells of the periapical region for maturogenesis. Five months radiograph follow-up showed thickening of lateral dentinal walls, which progress until 15 months resulting in apical closure, thickening of lateral dentinal walls and increase root length.
Related Concept Videos
Teeth
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
Bone Formation by Intramembranous Ossification
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...
Development of the Oral Microbiota
Embryonic Connective Tissues
The mesenchyme is the first connective tissue that emerges in the developing embryo. It consists of loosely arranged multipotent mesenchymal cells and reticular fibers in the extracellular matrix. This loose arrangement allows easy migration of cells, which is essential for germ layer positioning, patterning, and organ morphogenesis during embryonic development. Mesenchyme is...
Tooth Anatomy
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...

