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Related Experiment Video

Updated: May 8, 2026

Polygraphic Recording Procedure for Measuring Sleep in Mice

Polygraphic Recording Procedure for Measuring Sleep in Mice

Published on: January 25, 2016

Melatonin in perioperative medicine: Current perspective.

Souvik Maitra¹, Dalim Kumar Baidya, Puneet Khanna

¹Department of Anesthesiology and Intensive Care, All India Institute of Medical Sciences, New Delhi, India.

Saudi Journal of Anaesthesia

|September 10, 2013

Summary

Melatonin effectively reduces preoperative anxiety, similar to benzodiazepines, with fewer side effects. This makes melatonin a safe and effective alternative for peri-operative care.

Keywords:

Anxiolytic melatonin opioid sparing postoperative delirium

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Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

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Last Updated: May 8, 2026

Polygraphic Recording Procedure for Measuring Sleep in Mice

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Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

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Optogenetic Manipulation of Neural Circuits During Monitoring Sleep/wakefulness States in Mice

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Published on: June 19, 2019

Area of Science:

Anesthesiology
Pharmacology

Background:

Melatonin is increasingly recognized for its potential in peri-operative management.
Anxiety and psychomotor impairment are common concerns in the peri-operative period.

Purpose of the Study:

To evaluate melatonin as a pre-operative anxiolytic.
To compare its efficacy and side effect profile with benzodiazepines.

Main Methods:

Review of available clinical data on melatonin's use in peri-operative care.
Assessment of its impact on anxiety, psychomotor performance, and sleep-wake cycle.

Main Results:

Preoperative melatonin demonstrated efficacy comparable to benzodiazepines in reducing anxiety.
Melatonin exhibited minimal impact on psychomotor performance and the sleep-wake cycle.
Short-term administration showed no significant adverse effects.

Conclusions:

Melatonin is a safe and effective alternative to benzodiazepines for preoperative anxiety reduction.
Potential benefits include opioid-sparing effects, reduced intraocular pressure, and prevention of postoperative delirium.