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Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

Published on: July 28, 2023

Equine exuberant granulation tissue and human keloids: a comparative histopathologic study.

Christine L Theoret¹, Oluyinka O Olutoye, Laura K S Parnell

¹Université de Montréal, Saint-Hyacinthe, Québec, Canada.

Veterinary Surgery : VS

|September 11, 2013

Summary

Exuberant granulation tissue (EGT) in horses and keloids in humans share collagen similarities but differ in myofibroblasts and inflammation. These findings in fibroproliferative disorders may inform future treatment strategies.

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Area of Science:

Comparative histopathology
Veterinary dermatology
Human dermatopathology

Background:

Exuberant granulation tissue (EGT) in horses and keloids in humans are fibroproliferative disorders of wound healing.
Limited comparative data exists on their histopathologic features, particularly regarding fibroblast populations and collagen characteristics.

Purpose of the Study:

To compare the histopathologic features of EGT in horses and keloids in humans.
To identify similarities and differences in collagen, cellularity, inflammation, and vascularity between these conditions.

Main Methods:

Histochemical and immunohistochemical staining of archival tissue samples from horses with EGT (n=8) and humans with keloids (n=12).
Semi-quantitative grading of ulceration, keloidal collagen, myofibroblasts, elastic fibers, inflammation, fibrosis, vascularity, and collagen fiber orientation.

Main Results:

Both EGT and keloids exhibited increased haphazardly oriented collagen fibers; only keloids showed "keloidal" collagen.
EGT displayed myofibroblasts and increased acute inflammatory cells, while keloids did not.
Superficial dermis in EGT featured small vessels within immature granulation tissue, unlike keloids.

Conclusions:

Horses and humans are unique in naturally developing excessive granulation during wound healing.
Differences in inflammatory response, myofibroblasts, and vascularity may distinguish EGT from keloids.
Further research is needed to develop unified treatment strategies for these fibroproliferative conditions.