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Outcomes of children after esophagogastroduodenoscopy for chronic abdominal pain
Kalpesh Thakkar1, Leon Chen1, Mary E Tessier1
1Section of Pediatric Gastroenterology, Hepatology and Nutrition, Baylor College of Medicine, Houston, Texas.
Insights
Esophagogastroduodenoscopy (EGD) accurately diagnosed 38% of children with chronic abdominal pain. This procedure identified treatable conditions, with 67% of patients responding well to medical therapy within a year.
Area of Science:
- Pediatric Gastroenterology
- Diagnostic Endoscopy
Background:
- Chronic abdominal pain is a common reason for pediatric esophagogastroduodenoscopy (EGD).
- Limited data exists on the diagnostic accuracy and patient outcomes following EGD for this indication.
Purpose of the Study:
- To evaluate the diagnostic yield of EGD in children with chronic abdominal pain.
- To assess the short-term outcomes of pediatric patients undergoing EGD for abdominal pain.
Main Methods:
- A prospective study included 290 children (4-18 years) with chronic abdominal pain undergoing EGD.
- Data collected included demographics, alarm features, Rome III criteria, and EGD findings.
- Patients with diagnostic lesions were followed for at least one year for outcomes.
Main Results:
- EGD provided an accurate diagnosis in 38% of children.
- Common diagnoses included esophagitis (21.0%), eosinophilic gastroenteritis (4.1%), and H. pylori infection (2.0%).
- Medical therapy was effective in approximately 67% of patients with diagnostic findings.
Conclusions:
- EGD is a valuable diagnostic tool for pediatric chronic abdominal pain, with a 38% diagnostic yield.
- The procedure identifies treatable gastrointestinal disorders, leading to effective medical management in a majority of cases.
Background & Aims:
Chronic abdominal pain is the most common indication for esophagogastroduodenoscopy (EGD) in children. However, little is known about the accuracy of EGD-based diagnosis or the outcomes of the patients who undergo this procedure. We examined the diagnostic yield of EGD and short-term outcomes of children who underwent this procedure for chronic abdominal pain.
Methods:
We conducted a prospective study of 290 children (4-18 years old; mean age, 11.9 ± 3.5 years; 93 girls) who underwent EGD for the primary indication of chronic abdominal pain (216 with at least 1 alarm feature) at a US pediatric gastroenterology referral center. We collected data on demographic features (age, sex), clinical characteristics (alarm features, Rome III criteria), and EGD results for each patient. All subjects with diagnostic lesions were followed for at least 1 year after EGD to determine short-term outcomes.
Results:
Overall, EGD provided an accurate diagnosis for 109 children (38%). Diagnoses included esophagitis (21.0%), eosinophilic gastroenteritis (4.1%), eosinophilic esophagitis (3.8%), Helicobacter pylori infection (2.0%), celiac disease (0.6%), and Crohn's disease (0.4%). Short-term outcomes were available for 81% of patients with diagnostic findings, and medical therapy was effective in approximately 67% of these children.
Conclusions:
EGD is valuable for the diagnosis of children with abdominal pain, with a 38% diagnostic yield. EGD identified disorders for which medical therapy was effective in 67% of children during the year after diagnosis.
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