Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calcium overload in human giant cell myocarditis.

H G Olbrich1, G Herrmann, G Vandeplassche

  • 1Abteilung für Kardiologie, Universität Frankfurt, Federal Republic of Germany.

Journal of Clinical Pathology
|August 1, 1990
PubMed
Summary

Giant cell myocarditis can cause myocardial calcium overload. This study found calcium accumulation in viable heart cells, not just after cell death, suggesting an early role in disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Management of traumatic brain injury in the non-neurosurgical intensive care unit: a narrative review of current evidence.

Anaesthesia·2023
Same author

Dark Energy Survey Year 1 Results: Cosmological Constraints from Cluster Abundances, Weak Lensing, and Galaxy Correlations.

Physical review letters·2021
Same author

Constraints on Dark Matter Properties from Observations of Milky Way Satellite Galaxies.

Physical review letters·2021
Same author

Genital lichen sclerosus in women: a histopathological analysis of 38 criteria.

Journal of the European Academy of Dermatology and Venereology : JEADV·2020
Same author

The antioxidative enzyme SOD2 is important for physiological persistence of corpora lutea in lynxes.

Scientific reports·2020
Same author

Cosmological Constraints from Multiple Probes in the Dark Energy Survey.

Physical review letters·2019

Area of Science:

  • Cardiovascular Pathology
  • Cell Biology
  • Myocardial Research

Background:

  • Giant cell myocarditis is a rare and severe inflammatory heart condition.
  • Myocardial calcium overload is implicated in various heart diseases, but its role in giant cell myocarditis is unclear.

Observation:

  • A patient with giant cell myocarditis exhibited significant myocardial calcium overload (120 mEq/kg dry weight).
  • Histological examination revealed patchy calcification of myocardial fibers.
  • Ultrastructural analysis using the phosphate-pyroantimonate method showed altered subcellular calcium distribution.

Findings:

  • In normal myocytes, calcium precipitates were localized to the sarcolemma, T-tubules, intercalated disks, and mitochondria.
  • Necrotic myocytes showed extensive mitochondrial calcification and loss of sarcolemmal calcium.

Related Experiment Videos

  • Crucially, viable myocytes displayed increased mitochondrial calcium precipitates, even with minor mitochondrial swelling.

    • Implications:

    • These findings suggest that myocardial calcium overload in giant cell myocarditis may originate in viable myocytes.
    • This challenges the notion that calcium overload is solely a post-mortem phenomenon.
    • Understanding the timing of calcium dysregulation could inform therapeutic strategies for inflammatory cardiomyopathies.