Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Accessory Structures of the Skin: Hair Growth and Types01:20

Accessory Structures of the Skin: Hair Growth and Types

Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. Hair can be cut or shaven without damaging the hair structure because the cut is superficial. Most...
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
Accessory Structures of the Skin: Hair and Hair Follicles01:16

Accessory Structures of the Skin: Hair and Hair Follicles

Hair and hair follicles are integral components of the integumentary system. Hair is a filamentous structure composed mainly of a protein called keratin. It is found on the surface of the skin throughout the body, except for areas such as the palms of the hands and soles of the feet.
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dental pulp stem cell-derived exosomes attenuate psoriatic inflammation by restoring epithelial redox homeostasis via a miR-1246/miR-17-3p-GPX2-NF-κB axis.

Stem cell research & therapy·2026
Same author

Isolation and Characterization of Dental Pulp Stem Cell-Derived Exosomes Across Cell Passages.

Journal of visualized experiments : JoVE·2026
Same author

Editorial Expression of Concern: Opposing roles for calcineurin and ATF3 in squamous skin cancer.

Nature·2026
Same author

Standardized Method to Detect Tunneling Nanotubes in Human Skin Cells for Tissue Engineering Applications.

Journal of visualized experiments : JoVE·2026
Same author

Single-Cell transcriptomic analysis reveals distinct cellular and molecular signatures of human oral mucosa and skin.

Cellular and molecular life sciences : CMLS·2026
Same author

UV induces common cutaneous amyloid-like melanosomal protein aggregates.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: May 8, 2026

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin
08:26

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin

Published on: March 31, 2011

Future horizons in hair restoration.

Bryan T Marshall1, Chris A Ingraham, Xunwei Wu

  • 1Aderans Research Institute, 2211 Newmarket Parkway, Suite 142, Marietta, GA 30067, USA.

Facial Plastic Surgery Clinics of North America
|September 11, 2013
PubMed
Summary

This review explores hair follicle regeneration using cell fragments and cultures. Recent advancements and new cell sources offer promising avenues for restoring hair growth.

Keywords:
Cell therapyDermal papillaHair follicleHair transplantationInduced pluripotent stem cells (iPS)Regenerative medicineTrichogenicity

More Related Videos

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
06:41

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis

Published on: March 9, 2015

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration
10:09

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

Published on: February 28, 2013

Related Experiment Videos

Last Updated: May 8, 2026

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin
08:26

Isolation and Culture of Adult Epithelial Stem Cells from Human Skin

Published on: March 31, 2011

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
06:41

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis

Published on: March 9, 2015

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration
10:09

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration

Published on: February 28, 2013

Area of Science:

  • Regenerative Medicine
  • Dermatology
  • Tissue Engineering

Background:

  • Hair loss affects millions globally, necessitating effective regeneration strategies.
  • Current treatments offer limited efficacy, driving research into novel regenerative approaches.
  • Hair follicle regeneration holds potential for restoring natural hair growth.

Purpose of the Study:

  • To review the historical progress in hair follicle regeneration.
  • To discuss challenges and recent achievements in regenerating human hair follicles.
  • To explore novel cell sources for future hair regeneration therapies.

Main Methods:

  • Review of historical data and scientific literature on hair follicle regeneration.
  • Analysis of in vitro culture techniques and cell dissociation methods.
  • Evaluation of clinical studies and cosmetic acceptance of hair regeneration outcomes.

Main Results:

  • Significant progress has been made in regenerating hair follicles from various cell sources.
  • In vitro culture and delivery of regenerated follicles present ongoing challenges.
  • Recent achievements include successful regeneration of human hair follicles in preclinical models.

Conclusions:

  • Hair follicle regeneration is a rapidly advancing field with significant therapeutic potential.
  • Overcoming in vitro culture and delivery challenges is crucial for clinical translation.
  • Exploration of new cell sources and refining existing methods will drive future success in hair regeneration.