Related Experiment Video

Updated: May 8, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

Sedation for paediatric transcatheter atrial septal defect closure: comparison of two sedation protocols

Ayşe Ülgey1, Adnan Bayram1, Işın Güneş1

  • 11Department of Anaesthesiology,Erciyes University Medical Faculty,Kayseri,Turkey.

Cardiology in the Young
|September 11, 2013
PubMed

Insights

Ketamine-propofol sedation offers greater hemodynamic stability in pediatric atrial septal defect closures compared to dexmedetomidine-propofol. Both sedation methods resulted in similar recovery times for children undergoing the procedure.

Area of Science:

  • Pediatric Cardiology
  • Anesthesiology
  • Pharmacology

Background:

  • Transcatheter closure of atrial septal defects (ASDs) is a common pediatric cardiac procedure.
  • Sedation is crucial for patient comfort and procedural success during ASD closure.
  • Different anesthetic agents may have varying effects on hemodynamic stability and recovery.

Purpose of the Study:

  • To compare the efficacy of dexmedetomidine-propofol versus ketamine-propofol sedation.
  • To evaluate hemodynamic stability, immobility, and recovery time in pediatric patients undergoing transcatheter ASD closure.
  • To determine the optimal sedation strategy for this specific pediatric cardiac intervention.

Main Methods:

  • A study involving 46 pediatric patients scheduled for transcatheter ASD closure.
  • Two groups were formed: dexmedetomidine-propofol (n=23) and ketamine-propofol (n=23).
  • Specific induction and maintenance dosages for each anesthetic combination were administered.

Main Results:

  • The dexmedetomidine-propofol group showed significantly more instances of decreased mean arterial pressure (47.8%) and heart rate (43.4%) compared to the ketamine-propofol group (4.3% and 13%, respectively).
  • Lower heart rates were consistently observed in the dexmedetomidine group after the initial 10 minutes.
  • Recovery times were comparable between the two groups (15.86 ± 6.50 min vs. 19.65 ± 8.19 min).

Conclusions:

  • Ketamine-propofol sedation is associated with less hemodynamic instability in pediatric ASD closure compared to dexmedetomidine-propofol.
  • The ketamine-propofol combination provided adequate conditions for the transcatheter intervention.
  • No significant difference in recovery times was noted between the two sedation regimens.
Abstract

More Related Videos

Non-Intubated Video-Assisted Thoracoscopic Surgery05:39

Non-Intubated Video-Assisted Thoracoscopic Surgery

Published on: May 26, 2023

Related Concept Videos

Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
Stages of General Anesthesia01:22

Stages of General Anesthesia

Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
General Anesthesia: Overview01:24

General Anesthesia: Overview

Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
Sedatives and Hypnotics: Overview01:23

Sedatives and Hypnotics: Overview

Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
Inhalational Anesthetics: Overview01:20

Inhalational Anesthetics: Overview

Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...