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[The role of platelet activating factor in ovulation]
Y Kikukawa1, M Ishikawa, K Sengoku
1Department of Obstetrics and Gynecology, Asahikawa Medical College, Hokkaido.
Nihon Sanka Fujinka Gakkai Zasshi
|June 1, 1990
Summary
Platelet-activating factor (PAF) plays a role in ovulation. Blocking PAF receptors inhibits ovulation, but prostaglandins do not enhance this effect, suggesting PAF
Area of Science:
- Reproductive Biology
- Inflammation and Immunology
Context:
- Ovulation involves inflammation-like processes.
- Platelet-activating factor (PAF) is implicated in inflammation.
Purpose:
- To investigate the role of PAF in PMSG-HCG induced ovulation.
- To assess the effect of PAF receptor antagonist CV3988 on ovulation.
- To determine if prostaglandins (PGs) interfere with PAF-mediated ovulation.
Summary:
- CV3988, a PAF receptor antagonist, blocked ovulation in a dose-dependent manner in hyperovulated mice.
- Reduced ovulatory efficiency was observed at doses above 500 micrograms.
- PAF administration recovered ovulation blocked by CV3988, while ovarian PGs increased during blockade reversal.
Impact:
- Suggests a significant role for PAF in the ovulation process.
- Indicates that PGs may not potentiate PAF's function in ovulation.