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Updated: May 8, 2026

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From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
Published on: January 13, 2017
Isolation and structural determination of makinolide B from Streptomyces sp. MK-19
Michitaka Hidaki1, Mitsuru Yoshida, Naoto Ogawa
1Graduate School of Agriculture, Shizuoka University.
Bioscience, Biotechnology, and Biochemistry
|September 11, 2013
Abstract:
A new 16-membered macrolide named makinolide B (1) was isolated from Streptomyces sp. MK-19. The structure of makinolide B (1) was determined on the basis of 2D NMR experiments involving DQF-COSY, TOCSY, HSQC, and HMBC methods. Application of the paper disk diffusion method to makinolide B (1) showed weak antibacterial activity against Staphylococcus aureus at the dose of 100 µg/disk.
