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Updated: May 8, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
Published on: April 7, 2017
Epithelial-mesenchymal transition phenotype is associated with patient survival in small intestinal adenocarcinoma
Aeri Kim1, Young Kyung Bae, Mi Jin Gu
1*Departments of Pathology, Yeungnam University College of Medicine, Daegu †Chonbuk National University Medical School, Jeonju ‡Inje University Sanggye Paik Hospital, Seoul §Kyungpook National University School of Medicine, Daegu ||Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea ¶currently Department of Pathology, Daegu Fatima Hospital, Daegu, South Korea.
Aims:
We investigated the clinical significance of epithelial-mesenchymal transition (EMT) phenotype in 184 small intestinal adenocarcinomas (SIACs) based on the expression pattern of EMT-related proteins in cancer cells.
Methods:
Immunohistochemistry for epithelial (E-cadherin) and mesenchymal (vimentin and fibronectin) markers were performed and cases of SIAC were classified into four subtypes of EMT: complete type (E-cadherin-, vimentin+ and/or fibronectin+), wild type (E-cadherin+, vimentin-, fibronectin-), incomplete 1 type (hybrid type; E-cadherin+, vimentin+ and/or fibronectin+), and incomplete 2 type (null type; E-cadherin-, vimentin-, fibronectin-).
Results:
We identified 19 (10.3%) cases of complete EMT type, 86 (46.7%) cases of wild type and 79 (43%) cases of incomplete EMT type [hybrid type, 22 (12%) cases; null type, 57 (31%) cases]. Complete EMT phenotype showed a significant association with undifferentiated histology (p<0.001). Overall survival of SIAC patients with complete EMT phenotype was significantly shorter than those of patients with incomplete (p=0.001) and wild (p<0.001) types. In multivariate analysis, complete EMT phenotype was an independent prognostic factor in SIAC patients (hazard ratio 2.3; 95% confidence interval 1.15-4.6; p=0.019).
Conclusion:
Complete EMT phenotype stratifies a specific group representing a poor clinical outcome in patients with SIAC.
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