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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...

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Related Experiment Video

Updated: May 8, 2026

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
08:48

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

[Multiple sclerosis and physical activity: an historical perspective].

A Tallner1, M Mäurer, K Pfeifer

  • 1Institut für Sportwissenschaft und Sport, Friedrich-Alexander-Universität Erlangen-Nürnberg, Gebbertstr. 123b, 91058, Erlangen, Deutschland, Alexander.Tallner@sport.uni-erlangen.de.

Der Nervenarzt
|September 11, 2013
PubMed
Summary
This summary is machine-generated.

Physical activity and exercise offer therapeutic benefits for multiple sclerosis, shifting from past fears to established positive effects. Further high-quality research is needed for specific training recommendations.

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Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
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Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

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Related Experiment Videos

Last Updated: May 8, 2026

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
08:48

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

The Multiple Sclerosis Performance Test (MSPT): An iPad-Based Disability Assessment Tool
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Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI
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Methods to Quantify Pharmacologically Induced Alterations in Motor Function in Human Incomplete SCI

Published on: April 18, 2011

Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Exercise Science

Context:

  • Historically, multiple sclerosis (MS) pathology generated numerous theories on cause and therapy.
  • Significant technological advancements and scientific methods over 40 years have expanded MS knowledge.
  • Attitudes toward physical activity in MS have shifted from potential harm to recognized therapeutic benefits.

Purpose:

  • To review the evolution of understanding regarding physical activity and exercise in multiple sclerosis.
  • To highlight the paradigm shift in therapeutic approaches for MS management.
  • To identify current gaps in high-quality research concerning exercise in MS.

Summary:

  • Early evidence for exercise benefits in MS emerged in the 1960s, with scientific interest surging in the 1990s.
  • The positive effects of physical activity and exercise for multiple sclerosis are now well-established.
  • Despite established benefits, high-quality research on specific training effects and recommendations remains limited.

Impact:

  • This review underscores the established role of exercise in managing multiple sclerosis.
  • It emphasizes the need for continued rigorous research to refine exercise protocols for MS patients.
  • Improved understanding can lead to evidence-based, personalized exercise recommendations for enhanced patient outcomes.