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Published on: November 9, 2019
A general strategy for the synthesis of P-stereogenic compounds
Olivier Berger1, Jean-Luc Montchamp
1Department of Chemistry, Box 298860, Texas Christian University, Fort Worth, TX 76133 (USA).
Abstract:
A great leap forward toward the general synthesis of P-stereogenic compounds: Heating H3 PO2 with (-)-menthol and paraformaldehyde gives easily crystallized menthyl hydroxymethyl-H-phosphinate (1). From this product, virtually any P-stereogenic compound can be synthesized.
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