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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Menopause01:28

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Infertility in Males01:23

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...

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Updated: May 8, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Osteoporosis in men.

Jennifer S Walsh1, Richard Eastell

  • 1Academic Unit of Bone Metabolism, Sorby Wing, Northern General Hospital, Herries Road, Sheffield S5 7AU, UK.

Nature Reviews. Endocrinology
|September 11, 2013
PubMed
Summary
This summary is machine-generated.

Osteoporosis in men is underdiagnosed and undertreated, despite significant health risks. This review covers male osteoporosis pathophysiology, diagnosis, and treatment, referencing 2012 Endocrine Society guidelines.

Related Experiment Videos

Last Updated: May 8, 2026

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
08:56

Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats

Published on: April 7, 2023

Area of Science:

  • Geriatric Medicine
  • Endocrinology
  • Bone Health

Background:

  • Osteoporotic fractures are common in men over 50, leading to significant mortality and morbidity.
  • Male osteoporosis is frequently underdiagnosed and undertreated.
  • Secondary osteoporosis causes in men include androgen deprivation therapy, glucocorticoids, and excessive alcohol consumption.

Purpose of the Study:

  • To review the pathophysiology of osteoporosis in men.
  • To evaluate the evidence for testing and treating osteoporosis in men.
  • To inform clinical practice by discussing the current evidence base and 2012 Endocrine Society guidelines.

Main Methods:

  • Literature review of osteoporosis in men.
  • Analysis of clinical trial data on osteoporosis treatments.
  • Examination of diagnostic and treatment guidelines.

Main Results:

  • Pharmacological treatments increase bone mineral density (BMD) and decrease bone turnover markers in men.
  • Few trials have specifically evaluated fracture reduction as an endpoint in male osteoporosis treatment.
  • The 2012 Endocrine Society guidelines provide a framework for clinical practice.

Conclusions:

  • Osteoporosis management in men requires greater clinical attention.
  • Further research is needed on fracture reduction endpoints for male osteoporosis treatments.
  • Adherence to established guidelines is crucial for improving patient outcomes.